La ricerca di Diane S. Lidke si concentra sull'applicazione della microscopia a fluorescenza e delle tecniche biofisiche allo studio della trasduzione del segnale cellulare. Il tema del lavoro del Dr. Lidke è visualizzare e quantificare le dinamiche proteiche che regolano la segnalazione cellulare, sia nello stato normale che in quello malato. L'obiettivo finale è identificare i meccanismi molecolari che alterano la segnalazione nel cancro e la risposta immunitaria.
Research in the Lidke Laboratory integrates the disciplines of biophysics, bio-imaging and quantitative biology to gain new and fundamental understanding of the components and dynamics of cell signaling pathways. This involves the measurement of protein behavior in living cells to capture and quantify biochemical events that initiate signaling. The focus is on the study of the receptor tyrosine kinases and immunoreceptors, and how these are altered in disease or influenced by therapeutics.
Diane Lidke, Ph.D.
Professor & Vice-Chair for Research, Department of Pathology
Lidke ha conseguito la laurea in Fisica nel 1994. Ha conseguito il dottorato di ricerca in Scienze biofisiche e fisica medica presso l'Università del Minnesota nel 2002. La sua ricerca post-dottorato è stata nel laboratorio di Thomas Jovin presso il Max Planck Institute for Biophysical Chemistry a Goettingen, in Germania . È entrata a far parte del Dipartimento di Patologia dell'UNM nel 2005.
N.L. Andrews, J.R. Pfeiffer, A.M. Martinez, D.M. Haaland, R.W. Davis, T. Kawakami, J.M. Oliver, B.S. Wilson and D.S. Lidke. Small, mobile FcRI aggregates are signaling competent. Immunity, 31: 469-479 (2009) PMC2828771
S.T. Low-Nam, K.A. Lidke, P.J. Cutler, R.C. Roovers, P.M.P. van Bergen en Henegouwen, B.S. Wilson, D.S. Lidke. ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand. Nature Structural & Molecular Biology, 18: 1244-1249 (2011) PMC3210321
S.L. Schwartz, C. Cleyrat, M. Olah, P. Relich, G. Phillips, W.S. Hlavacek, K.A. Lidke, B.S. Wilson and D.S. Lidke. Differential mast cell outcomes are sensitive to FcRI-Syk binding kinetics. Molecular Biology of the Cell - Quantitative Biology Special Issue 28: 3397-3414 (2017) PMC5687039**MBoC Highlight article
A.M. Brandsma*, S.L. Schwartz*, C.C. Valley, G.L.A. Blezer, G. Vidarsson, K.A. Lidke, T. ten Broeke, D.S. Lidke^, J.H.W. Leusen^. Mechanisms of inside-out signaling of the high affinity IgG-receptor FcRI. Science Signaling. 11: eaaq0891 (2018) PMID: 30042128 ^Lidke and Leusen are co-corresponding authors.
E. Salazar-Cavazos, C. Franco Nitta, E.D. Mitra, B.S. Wilson, K.A. Lidke, W.S. Hlavacek, Lidke, D.S. Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes. Molecular Biology of the Cell, 19:695-708 (2020) PMC7202077
Research in the Lidke Laboratory integrates the disciplines of biophysics, bio-imaging and quantitative biology to gain new and fundamental understanding of the components and dynamics of cell signaling pathways. This involves the measurement of protein behavior in living cells to capture and quantify biochemical events that initiate signaling. The focus is on the study of the receptor tyrosine kinases and immunoreceptors, and how these are altered in disease or influenced by therapeutics.
Diane Lidke, Ph.D.
Professor & Vice-Chair for Research, Department of Pathology
Lidke ha conseguito la laurea in Fisica nel 1994. Ha conseguito il dottorato di ricerca in Scienze biofisiche e fisica medica presso l'Università del Minnesota nel 2002. La sua ricerca post-dottorato è stata nel laboratorio di Thomas Jovin presso il Max Planck Institute for Biophysical Chemistry a Goettingen, in Germania . È entrata a far parte del Dipartimento di Patologia dell'UNM nel 2005.
N.L. Andrews, J.R. Pfeiffer, A.M. Martinez, D.M. Haaland, R.W. Davis, T. Kawakami, J.M. Oliver, B.S. Wilson and D.S. Lidke. Small, mobile FcRI aggregates are signaling competent. Immunity, 31: 469-479 (2009) PMC2828771
S.T. Low-Nam, K.A. Lidke, P.J. Cutler, R.C. Roovers, P.M.P. van Bergen en Henegouwen, B.S. Wilson, D.S. Lidke. ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand. Nature Structural & Molecular Biology, 18: 1244-1249 (2011) PMC3210321
S.L. Schwartz, C. Cleyrat, M. Olah, P. Relich, G. Phillips, W.S. Hlavacek, K.A. Lidke, B.S. Wilson and D.S. Lidke. Differential mast cell outcomes are sensitive to FcRI-Syk binding kinetics. Molecular Biology of the Cell - Quantitative Biology Special Issue 28: 3397-3414 (2017) PMC5687039**MBoC Highlight article
A.M. Brandsma*, S.L. Schwartz*, C.C. Valley, G.L.A. Blezer, G. Vidarsson, K.A. Lidke, T. ten Broeke, D.S. Lidke^, J.H.W. Leusen^. Mechanisms of inside-out signaling of the high affinity IgG-receptor FcRI. Science Signaling. 11: eaaq0891 (2018) PMID: 30042128 ^Lidke and Leusen are co-corresponding authors.
E. Salazar-Cavazos, C. Franco Nitta, E.D. Mitra, B.S. Wilson, K.A. Lidke, W.S. Hlavacek, Lidke, D.S. Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes. Molecular Biology of the Cell, 19:695-708 (2020) PMC7202077
Diane S. Lidke. dottorato di ricerca
Dipartimento di Patologia
Centro di ricerca sul cancro, stanza 203
Facoltà di Medicina dell'Università del New Mexico
Albuquerque, New Mexico 87131